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1245734-61-5

1245734-61-5 structure
1245734-61-5 structure
  • Name: TK05
  • Chemical Name: TK05
  • CAS Number: 1245734-61-5
  • Molecular Formula: C31H25ClN2O5
  • Molecular Weight: 540.99
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Gutathione S-transferase
  • Create Date: 2019-06-01 17:17:50
  • Modify Date: 2025-08-26 19:38:32
  • TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].

Name TK05
Description TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].
Related Catalog
Target

IC50: 95 nM (Leukotriene C4 synthase)[1]

In Vitro TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].
In Vivo TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. Animal Model: Zymosan A induced peritonitis mouse model[1] Dosage: 0.12 mg/kg; 6 mg/kg Administration: Given i.p.; only once Result: 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.
References

[1]. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16.

Molecular Formula C31H25ClN2O5
Molecular Weight 540.99
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