| Description |
TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].
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| Related Catalog |
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| Target |
IC50: 95 nM (Leukotriene C4 synthase)[1]
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| In Vitro |
TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].
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| In Vivo |
TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. Animal Model: Zymosan A induced peritonitis mouse model[1] Dosage: 0.12 mg/kg; 6 mg/kg Administration: Given i.p.; only once Result: 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.
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| References |
[1]. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16.
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