246020-68-8

246020-68-8 structure

Name: TRi-1(TXNRD1 inhibitor 1)
Chemical Name: TRi-1
CAS Number: 246020-68-8
Molecular Formula: C₁₂H₉ClN₂O₅S
Molecular Weight: 328.73
Catalog: Research Areas Cancer
Create Date: 2019-06-01 15:02:42
Modify Date: 2024-01-08 11:58:46
TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].

Name	TRi-1

Description	TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 12 nM (TXNRD1)[1].
References	[1]. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.