TRi-1(TXNRD1 inhibitor 1)

Modify Date: 2024-01-08 11:58:46

TRi-1(TXNRD1 inhibitor 1) Structure
TRi-1(TXNRD1 inhibitor 1) structure
Common Name TRi-1(TXNRD1 inhibitor 1)
CAS Number 246020-68-8 Molecular Weight 328.73
Density N/A Boiling Point N/A
Molecular Formula C12H9ClN2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TRi-1(TXNRD1 inhibitor 1)


TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].

 Names

Name TRi-1

 TRi-1(TXNRD1 inhibitor 1) Biological Activity

Description TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
Related Catalog
Target

IC50: 12 nM (TXNRD1)[1].

References

[1]. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.

 Chemical & Physical Properties

Molecular Formula C12H9ClN2O5S
Molecular Weight 328.73
Storage condition 2-8℃
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