2349374-37-2
2349374-37-2 structure
- Name: 15-LOX-1 inhibitor 1
- Chemical Name: 9c(i472)
- CAS Number: 2349374-37-2
- Molecular Formula: C22H21ClN2O4
- Molecular Weight: 412.866
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
- Create Date: 2021-08-11 18:38:00
- Modify Date: 2024-01-09 19:26:17
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15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1].
| Name | 9c(i472) |
|---|---|
| Synonyms |
Ethyl 6-chloro-3-{(1E)-3-[(2-methoxybenzyl)amino]-3-oxo-1-propen-1-yl}-1H-indole-2-carboxylate
9c(i472) 1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester |
| Description | 15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1]. |
|---|---|
| Related Catalog | |
| Target |
15-LOX-1:0.19 μM (IC50) |
| In Vitro | 15-LOX-1 inhibitor 1 (Compound 9c) (0-5 μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM[1]. Cell Viability Assay[1] Cell Line: RAW 264.7 macrophages Concentration: 0, 0.2, 1, 5 μM 15-LOX-1 inhibitor 1 and lipopolysaccharides (LPS) (100 μg/mL) Incubation Time: 24 hours Result: Showed stronger, dose-dependent effects with a 20% viability increase at 5 μM. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 683.5±55.0 °C at 760 mmHg |
| Molecular Formula | C22H21ClN2O4 |
| Molecular Weight | 412.866 |
| Flash Point | 367.2±31.5 °C |
| Exact Mass | 412.118988 |
| LogP | 4.74 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.648 |