2097938-51-5
2097938-51-5 structure
- Name: R-10015
- Chemical Name: R-10015
- CAS Number: 2097938-51-5
- Molecular Formula: C20H19ClN6O2
- Molecular Weight: 410.86
- Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
- Create Date: 2019-06-30 12:32:15
- Modify Date: 2024-01-16 10:14:17
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R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1[1].
| Name | R-10015 |
|---|
| Description | R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1[1]. |
|---|---|
| Related Catalog | |
| Target |
human LIMK1:38 nM (IC50) |
| In Vitro | R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells[1]. R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release[1]. R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) [1]. Western Blot Analysis[1] Cell Line: CEM-SS T cells Concentration: 100 μM Incubation Time: 0 hour,0.5 hour,1 hour,2 hours,4 hours Result: Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells. |
| In Vivo | R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections[1]. Animal Model: 6-8 weeks female C3H/HeN mice[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection Result: Displayed none indication of toxicity. |
| References |
| Molecular Formula | C20H19ClN6O2 |
|---|---|
| Molecular Weight | 410.86 |
| Hazard Codes | Xi |
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