1998725-11-3

1998725-11-3 structure

Name: JHU-083
Chemical Name: JHU-083
CAS Number: 1998725-11-3
Molecular Formula: C₁₄H₂₄N₄O₄
Molecular Weight: 312.36
Catalog: Research Areas Neurological Disease
Create Date: 2019-08-04 11:53:59
Modify Date: 2024-01-02 17:17:58
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2].

Name	JHU-083

Description	JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Glutamine[2]
References	[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.

Molecular Formula	C₁₄H₂₄N₄O₄
Molecular Weight	312.36