JHU-083

Modify Date: 2024-01-02 17:17:58

JHU-083 structure	Common Name	JHU-083
	CAS Number	1998725-11-3	Molecular Weight	312.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₂₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JHU-083

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2].

Name	JHU-083

Description	JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Glutamine[2]
References	[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.

Molecular Formula	C₁₄H₂₄N₄O₄
Molecular Weight	312.36

DC Chemicals Limited
China
Product Name: JHU-083
Price: $950.0/100mg $1800.0/250mg $3600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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