1884640-99-6

1884640-99-6 structure

Name: NI 42
Chemical Name: NI-42
CAS Number: 1884640-99-6
Molecular Formula: C₁₈H₁₅N₃O₃S
Molecular Weight: 353.40
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-08-03 19:19:59
Modify Date: 2024-01-06 14:28:47
NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/ 940 nM) with excellent selectivity over nonclass IV BRD proteins[1].

Name	NI-42

Description	NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/ 940 nM) with excellent selectivity over nonclass IV BRD proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRPF1:7.9 nM (IC50) BRPF2:48 nM (IC50) BRPF3:260 nM (IC50) BRPF1:40 nM (Kd) BRPF2:210 nM (Kd) BRPF3:940 nM (Kd) BRD4 (BD1):4500 nM (IC50) BRD7:82 nM (IC50) BRD9:310 nM (IC50) BRD9:1130 nM (Kd)
In Vitro	NI-42 shows IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively, and has a Kd of 1130 nM for BRD9[1].
References	[1]. Igoe N, et al. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680.

Molecular Formula	C₁₈H₁₅N₃O₃S
Molecular Weight	353.40