1262832-74-5

1262832-74-5 structure

Name: PF-956980
Chemical Name: PF-956980
CAS Number: 1262832-74-5
Molecular Formula: C₁₈H₂₆N₆O
Molecular Weight: 342.439
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2019-09-08 20:14:51
Modify Date: 2024-01-04 02:03:57
PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases[1].

Name	PF-956980
Synonyms	((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone Methanone, [(3R,4R)-4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinyl- {(3R,4R)-4-Methyl-3-[methyl(1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl}(1-pyrrolidinyl)methanone

Description	PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:2.2 μM (IC50) JAK2:23.1 μM (IC50) JAK3:59.9 μM (IC50)
In Vivo	The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog Spesies Dose (mg/kg) Cl (mL/min/Kg) Clunbound (mL/min/Kg) Vss (L/Kg) Terminal T1/2 (h) Oral Bioavailability Rat i.v. 0.5 48 >48,000 0.8 2.1 - Rat p.o. 1 - - - - <5% Dog i.v. 0.1 18 >18,000 1.0 2.0 -
References	[1]. Peter Jones, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786.