1430114-34-3

1430114-34-3 structure

Name: BMS-962212
Chemical Name: BMS-962212
CAS Number: 1430114-34-3
Molecular Formula: C₃₂H₂₈ClFN₈O₅
Molecular Weight: 659.07
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2019-09-09 13:32:50
Modify Date: 2026-07-01 15:47:05
BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity[1].

Name	BMS-962212
Synonyms	BMS96221 (S,E)-4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1- yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)- 1,2,3,4-tetrahydroisoquinoline-1-cboxamido)benzoic acid Benzoic acid, 4-[[[(1S)-2-[(2E)-3-[3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl]-1-oxo-2-propen-1-yl]-1,2,3,4-tetrahydro-5-(4-methyl-2-oxo-1-piperazinyl)-1-isoquinolinyl]carbonyl]amino] 4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-ca rboxamido)benzoic acid BMS-962212 (BMS962212)

Description	BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
References	[1]. Perera V, et al. First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects. Br J Clin Pharmacol. 2018 May;84(5):876-887.

Molecular Formula	C₃₂H₂₈ClFN₈O₅
Molecular Weight	659.07