Top Suppliers:I want be here


1191265-33-4

1191265-33-4 structure
1191265-33-4 structure
  • Name: CDDO-dhTFEA
  • Chemical Name: CDDO-dhTFEA
  • CAS Number: 1191265-33-4
  • Molecular Formula: C33H45F3N2O3
  • Molecular Weight: 574.72
  • Catalog: Signaling Pathways NF-κB Keap1-Nrf2
  • Create Date: 2019-11-07 19:21:37
  • Modify Date: 2024-01-11 10:46:23
  • CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].

Name CDDO-dhTFEA
Description CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].
Related Catalog
Target

NF-κB

Nrf2

References

[1]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.

[2]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8.

Molecular Formula C33H45F3N2O3
Molecular Weight 574.72
Storage condition 2-8°C