1680179-43-4

1680179-43-4 structure

1680179-43-4 structure

Name: TrkA-IN-1
Chemical Name: TrkA-IN-1
CAS Number: 1680179-43-4
Molecular Formula: C₂₅H₂₀N₄O
Molecular Weight: 392.45
Create Date: 2019-12-09 02:21:19
Modify Date: 2024-01-20 17:25:18
TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity[1].

Name	TrkA-IN-1

Description	TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity[1].
Target	TrkA:99 nM (IC50) TrkB:81 μM (IC50) TrkC:25 μM (IC50)
References	[1]. Su HP , et al. Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E297-E306.

Molecular Formula	C₂₅H₂₀N₄O
Molecular Weight	392.45