1537150-15-4

1537150-15-4 structure

Name: SMN2 modulator 27
Chemical Name: 3-Chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-1,3-thiazol-2-yl]benzamide
CAS Number: 1537150-15-4
Molecular Formula: C₁₄H₁₂ClFN₂O₂S
Molecular Weight: 326.774
Create Date: 2020-01-11 13:03:36
Modify Date: 2024-10-04 01:05:25
SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM; shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition; a novel therapeutic mechanism that should complement other modalities for treatment of SMA.

Name	3-Chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-1,3-thiazol-2-yl]benzamide
Synonyms	3-Chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-1,3-thiazol-2-yl]benzamide Benzamide, 3-chloro-4-fluoro-N-[5-(1-hydroxycyclobutyl)-2-thiazolyl]-

Description	SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM; shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition; a novel therapeutic mechanism that should complement other modalities for treatment of SMA.
References	References 1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610. View Related Products by Target SMN2 Modulator