1791396-45-6
1791396-45-6 structure
- Name: SUVN-502 mesylate hydrate
- Chemical Name: Dimesylate Dimesylate Monohydrate
- CAS Number: 1791396-45-6
- Molecular Formula: C23H34BrN3O10S3
- Molecular Weight: 688.629
- Create Date: 2020-01-12 12:20:50
- Modify Date: 2024-03-07 12:42:21
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SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease. Alzheimer Disease Phase 2 Clinical
| Name | Dimesylate Dimesylate Monohydrate |
|---|---|
| Synonyms |
Dimesylate Dimesylate Monohydrate
1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole methanesulfonate hydrate (1:2:1) 1H-Indole, 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-, methanesulfonate, hydrate (1:2:1) |
| Description | SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease. Alzheimer Disease Phase 2 Clinical |
|---|---|
| References | References 1. Nirogi R, et al. J Med Chem. 2017 Mar 9;60(5):1843-1859. 2. Nirogi R, et al. J Pharm Biomed Anal. 2017 Apr 14;145:423-430. View Related Products by Target 5-HT Receptor Alzheimer Disease |
| Molecular Formula | C23H34BrN3O10S3 |
|---|---|
| Molecular Weight | 688.629 |
| Exact Mass | 687.058960 |