1869921-96-9
1869921-96-9 structure
- Name: AA-CW236
- Chemical Name: AA-CW236
- CAS Number: 1869921-96-9
- Molecular Formula: C17H16ClF3N4O2
- Molecular Weight: 400.783
- Create Date: 2020-01-20 15:45:56
- Modify Date: 2023-01-15 22:23:36
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A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay.
| Name | AA-CW236 |
|---|---|
| Synonyms |
4-(2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole
AA-CW236 5-(Chloromethyl)-1-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole Isoxazole, 4-[2-[5-(chloromethyl)-4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]ethyl]-3,5-dimethyl- |
| Description | A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay. |
|---|---|
| References | References 1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5. View Related Products by Target DNA Methyltransferase (DNMT) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 535.0±60.0 °C at 760 mmHg |
| Molecular Formula | C17H16ClF3N4O2 |
| Molecular Weight | 400.783 |
| Flash Point | 277.4±32.9 °C |
| Exact Mass | 400.091400 |
| LogP | 3.46 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.582 |
| Storage condition | 2-8°C |