AA-CW236
Modify Date: 2023-01-15 22:23:36
AA-CW236 structure
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Common Name | AA-CW236 | ||
|---|---|---|---|---|
| CAS Number | 1869921-96-9 | Molecular Weight | 400.783 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 535.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H16ClF3N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 277.4±32.9 °C | |
Use of AA-CW236A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay. |
| Name | AA-CW236 |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay. |
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| References | References 1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5. View Related Products by Target DNA Methyltransferase (DNMT) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 535.0±60.0 °C at 760 mmHg |
| Molecular Formula | C17H16ClF3N4O2 |
| Molecular Weight | 400.783 |
| Flash Point | 277.4±32.9 °C |
| Exact Mass | 400.091400 |
| LogP | 3.46 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.582 |
| Storage condition | 2-8°C |
| 4-(2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole |
| AA-CW236 |
| 5-(Chloromethyl)-1-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole |
| Isoxazole, 4-[2-[5-(chloromethyl)-4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]ethyl]-3,5-dimethyl- |