80809-81-0
- Name: AA-861
- Chemical Name: docebenone
- CAS Number: 80809-81-0
- Molecular Formula: C21H26O3
- Molecular Weight: 326.42900
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
- Create Date: 2018-09-06 19:15:22
- Modify Date: 2024-01-08 18:41:12
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Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
| Name | docebenone |
|---|---|
| Synonyms |
Docebenona
aa-861 DOCEBENONE Docebenonum MFCD00210243 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione |
| Description | Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. |
|---|---|
| Related Catalog | |
| Target |
5-LO[1]. |
| In Vitro | Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production[1]. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently[2]. |
| In Vivo | Docebenone might protect experimental acute necrotizing pancreatitis in rats[3]. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M[4]. |
| Animal Admin | Rats[3] Pancreatitis is induced in rats by retrograde injection of 0.4 mL/kg body wt of 6% taurocholic acid into the pancreatic duct. The animals are divided into three groups: control group; administered Docebenone in a single dose of 30 mg/kg; and administered Docebenone in a single dose of 60 mg/kg. The following parameters are examined: serum amylase, lipase, trypsin, blood sugar, and survival rate[3]. |
| References |
| Molecular Formula | C21H26O3 |
|---|---|
| Molecular Weight | 326.42900 |
| Exact Mass | 326.18800 |
| PSA | 54.37000 |
| LogP | 3.52090 |
|
~93%
80809-81-0 |
| Literature: Shiraishi, Mitsuru; Terao, Shinji Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 8 p. 1591 - 1599 |
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80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
|
~%
80809-81-0 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 1591 - 1599 |
| Precursor 9 | |
|---|---|
| DownStream 0 | |
| HS Code | 2914690090 |
|---|---|
| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |