1883548-86-4

1883548-86-4 structure

Name: PF 06260933 dihydrochloride
Chemical Name: 5-(4-Chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride
CAS Number: 1883548-86-4
Molecular Formula: C₁₆H₁₅Cl₃N₄
Molecular Weight: 369.676
Create Date: 2020-01-11 18:26:51
Modify Date: 2024-01-12 09:41:51
PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.

Name	5-(4-Chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride
Synonyms	5-(4-Chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride [3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-, hydrochloride (1:2)

Description	PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.
References	References 1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. 2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995. View Related Products by Target MAP4K