1404454-02-9
1404454-02-9 structure
- Name: PF-719 dihydrochloride
- Chemical Name: PF-719 dihydrochloride
- CAS Number: 1404454-02-9
- Molecular Formula: C22H29Cl2F3N6O
- Molecular Weight: 521.41
- Create Date: 2020-01-11 16:21:51
- Modify Date: 2024-01-11 15:31:49
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PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.
| Name | PF-719 dihydrochloride |
|---|
| Description | PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
|---|---|
| References | References 1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. View Related Products by Target Focal Adhesion Kinase (FAK) |
| Molecular Formula | C22H29Cl2F3N6O |
|---|---|
| Molecular Weight | 521.41 |