1908414-82-3
1908414-82-3 structure
- Name: LMPTP inhibitor 23
- Chemical Name: N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide
- CAS Number: 1908414-82-3
- Molecular Formula: C28H36N4O
- Molecular Weight: 444.612
- Create Date: 2020-01-16 14:40:12
- Modify Date: 2024-02-04 22:37:37
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LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM; displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B; inhibits uncompetitively LMPTP with Ki of 846 nM, substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.
| Name | N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide |
|---|---|
| Synonyms |
MFCD31536319
Benzamide, N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]- N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide |
| Description | LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM; displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B; inhibits uncompetitively LMPTP with Ki of 846 nM, substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss. |
|---|---|
| References | References 1. Stanford SM, et al. Nat Chem Biol. 2017 Jun;13(6):624-632. View Related Products by Target Protein Phosphatase/PTP |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 657.7±55.0 °C at 760 mmHg |
| Molecular Formula | C28H36N4O |
| Molecular Weight | 444.612 |
| Flash Point | 351.6±31.5 °C |
| Exact Mass | 444.288910 |
| LogP | 4.87 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.613 |