1908414-82-3

1908414-82-3 structure

Name: LMPTP inhibitor 23
Chemical Name: N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide
CAS Number: 1908414-82-3
Molecular Formula: C₂₈H₃₆N₄O
Molecular Weight: 444.612
Create Date: 2020-01-16 14:40:12
Modify Date: 2024-02-04 22:37:37
LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM; displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B; inhibits uncompetitively LMPTP with Ki of 846 nM, substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.

Name	N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide
Synonyms	MFCD31536319 Benzamide, N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]- N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide

Description	LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM; displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B; inhibits uncompetitively LMPTP with Ki of 846 nM, substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.
References	References 1. Stanford SM, et al. Nat Chem Biol. 2017 Jun;13(6):624-632. View Related Products by Target Protein Phosphatase/PTP