2046250-48-8

2046250-48-8 structure

Name: K67
Chemical Name: K67
CAS Number: 2046250-48-8
Molecular Formula: C₂₉H₃₀N₂O₇S₂
Molecular Weight: 582.688
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2020-01-11 17:13:51
Modify Date: 2024-09-24 16:29:21
K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2; has specific inhibitory effect on the Nrf2 target genes, dramatically suppresses the proliferations of Huh1 cells and of Huh7 cells expressing phospho-mimetic p62.

Name	K67
Synonyms	N,N'-[2-(2-Oxopropyl)naphthalene-1,4-Diyl]bis(4-Ethoxybenzenesulfonamide) 2-Acetonyl-1,4-bis[(4-ethoxybenzensulfonyl)amino]naphthalene N,N'-(2-(2-Oxopropyl)naphthalene-1,4-diyl)bis(4-ethoxybenzenesulfonamide) Benzenesulfonamide, N,N'-[2-(2-oxopropyl)-1,4-naphthalenediyl]bis[4-ethoxy- N,N'-[2-(2-Oxopropyl)-1,4-naphthalenediyl]bis(4-ethoxybenzenesulfonamide) K67 N-[2-Acetonyl-4-(4-ethoxybenzenesulfonylamino)naphthalene-1-yl]-4-ethoxybenzenesulfonamide

Description	K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2; has specific inhibitory effect on the Nrf2 target genes, dramatically suppresses the proliferations of Huh1 cells and of Huh7 cells expressing phospho-mimetic p62.
References	References 1. Saito T, et al. Nat Commun. 2016 Jun 27;7:12030. View Related Products by Target Keap1-Nrf2