2046250-48-8
2046250-48-8 structure
- Name: K67
- Chemical Name: K67
- CAS Number: 2046250-48-8
- Molecular Formula: C29H30N2O7S2
- Molecular Weight: 582.688
- Catalog: Signaling Pathways NF-κB Keap1-Nrf2
- Create Date: 2020-01-11 17:13:51
- Modify Date: 2023-03-03 16:59:47
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K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2; has specific inhibitory effect on the Nrf2 target genes, dramatically suppresses the proliferations of Huh1 cells and of Huh7 cells expressing phospho-mimetic p62.
| Name | K67 |
|---|---|
| Synonyms |
N,N'-[2-(2-Oxopropyl)naphthalene-1,4-Diyl]bis(4-Ethoxybenzenesulfonamide)
2-Acetonyl-1,4-bis[(4-ethoxybenzensulfonyl)amino]naphthalene N,N'-(2-(2-Oxopropyl)naphthalene-1,4-diyl)bis(4-ethoxybenzenesulfonamide) Benzenesulfonamide, N,N'-[2-(2-oxopropyl)-1,4-naphthalenediyl]bis[4-ethoxy- N,N'-[2-(2-Oxopropyl)-1,4-naphthalenediyl]bis(4-ethoxybenzenesulfonamide) K67 N-[2-Acetonyl-4-(4-ethoxybenzenesulfonylamino)naphthalene-1-yl]-4-ethoxybenzenesulfonamide |
| Description | K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2; has specific inhibitory effect on the Nrf2 target genes, dramatically suppresses the proliferations of Huh1 cells and of Huh7 cells expressing phospho-mimetic p62. |
|---|---|
| References | References 1. Saito T, et al. Nat Commun. 2016 Jun 27;7:12030. View Related Products by Target Keap1-Nrf2 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 752.2±70.0 °C at 760 mmHg |
| Molecular Formula | C29H30N2O7S2 |
| Molecular Weight | 582.688 |
| Flash Point | 408.7±35.7 °C |
| Exact Mass | 582.149414 |
| LogP | 5.09 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.640 |