2173992-60-2
2173992-60-2 structure
- Name: UNC-2170 maleate
- Chemical Name: 3-Bromo-N-{3-[(2-methyl-2-propanyl)amino]propyl}benzamide (2Z)-2-butenedioate (1:1)
- CAS Number: 2173992-60-2
- Molecular Formula: C18H25BrN2O5
- Molecular Weight: 429.306
- Create Date: 2020-01-12 00:08:34
- Modify Date: 2023-02-02 12:30:58
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A small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain; highly cell permeant with no significant measureable cellular efflux; shows modestly potent, demonstrates at least 17-fold selectivity for 53BP1 as compared to nine other Kme reader proteins.
| Name | 3-Bromo-N-{3-[(2-methyl-2-propanyl)amino]propyl}benzamide (2Z)-2-butenedioate (1:1) |
|---|---|
| Synonyms |
3-Bromo-N-{3-[(2-methyl-2-propanyl)amino]propyl}benzamide (2Z)-2-butenedioate (1:1)
Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-, (2Z)-2-butenedioate (1:1) |
| Description | A small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain; highly cell permeant with no significant measureable cellular efflux; shows modestly potent, demonstrates at least 17-fold selectivity for 53BP1 as compared to nine other Kme reader proteins. |
|---|---|
| References | References 1. Perfetti MT, et al. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. View Related Products by Target MDM2-p53 |
| Molecular Formula | C18H25BrN2O5 |
|---|---|
| Molecular Weight | 429.306 |
| Exact Mass | 428.094666 |