1350549-36-8
1350549-36-8 structure
- Name: UNC-1062
- Chemical Name: UNC-1062
- CAS Number: 1350549-36-8
- Molecular Formula: C25H34N6O4S
- Molecular Weight: 514.640
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK TAM Receptor
- Create Date: 2020-01-12 00:29:50
- Modify Date: 2024-01-11 11:43:06
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UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM; shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3); inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells.
| Name | UNC-1062 |
|---|---|
| Synonyms |
UNC-1062
T7755XP5Y6 Cyclohexanol, 4-[6-(butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, trans- trans-4-{6-(Butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}cyclohexanol |
| Description | UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM; shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3); inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells. |
|---|---|
| References | References 1. Schlegel J, et al. J Clin Invest. 2013 May;123(5):2257-67. 2. Liu J, et al. Eur J Med Chem. 2013 Jul;65:83-93. 3. von Mässenhausen A, et al. Oncotarget. 2016 May 31;7(22):32678-94. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 744.0±70.0 °C at 760 mmHg |
| Molecular Formula | C25H34N6O4S |
| Molecular Weight | 514.640 |
| Flash Point | 403.8±35.7 °C |
| Exact Mass | 514.236206 |
| LogP | 2.66 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.697 |