544707-20-2
544707-20-2 structure
- Name: JNJ 10181457 dihydrochloride
- Chemical Name: 4-{3-[4-(1-Piperidinyl)-1-butyn-1-yl]benzyl}morpholine dihydrochloride
- CAS Number: 544707-20-2
- Molecular Formula: C20H28N2O.2HCl
- Molecular Weight: 385.371
- Create Date: 2020-01-11 23:06:51
- Modify Date: 2024-01-17 17:27:53
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JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3; promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats; increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit.
| Name | 4-{3-[4-(1-Piperidinyl)-1-butyn-1-yl]benzyl}morpholine dihydrochloride |
|---|---|
| Synonyms |
4-{3-[4-(1-Piperidinyl)-1-butyn-1-yl]benzyl}morpholine dihydrochloride
Morpholine, 4-[[3-[4-(1-piperidinyl)-1-butyn-1-yl]phenyl]methyl]-, hydrochloride (1:2) |
| Description | JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3; promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats; increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit. |
|---|---|
| References | References 1. Bonaventure P, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96. 2. Galici R, et al. Neuropharmacology. 2009 Jun;56(8):1131-7. 3. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87. View Related Products by Target Histamine Receptor |
| Molecular Formula | C20H28N2O.2HCl |
|---|---|
| Molecular Weight | 385.371 |
| Exact Mass | 384.173523 |