JNJ 10181457 dihydrochloride
Modify Date: 2024-01-17 17:27:53
JNJ 10181457 dihydrochloride structure
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Common Name | JNJ 10181457 dihydrochloride | ||
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| CAS Number | 544707-20-2 | Molecular Weight | 385.371 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H28N2O.2HCl | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ 10181457 dihydrochlorideJNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3; promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats; increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit. |
| Name | 4-{3-[4-(1-Piperidinyl)-1-butyn-1-yl]benzyl}morpholine dihydrochloride |
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| Synonym | More Synonyms |
| Description | JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3; promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats; increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit. |
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| References | References 1. Bonaventure P, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96. 2. Galici R, et al. Neuropharmacology. 2009 Jun;56(8):1131-7. 3. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87. View Related Products by Target Histamine Receptor |
| Molecular Formula | C20H28N2O.2HCl |
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| Molecular Weight | 385.371 |
| Exact Mass | 384.173523 |
| 4-{3-[4-(1-Piperidinyl)-1-butyn-1-yl]benzyl}morpholine dihydrochloride |
| Morpholine, 4-[[3-[4-(1-piperidinyl)-1-butyn-1-yl]phenyl]methyl]-, hydrochloride (1:2) |