1782228-76-5
1782228-76-5 structure
- Name: JNJ 5207852 dihydrochloride
- Chemical Name: JNJ-5207852 dihydrochloride
- CAS Number: 1782228-76-5
- Molecular Formula: C20H34Cl2N2O
- Molecular Weight: 389.40
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2020-08-11 17:45:06
- Modify Date: 2024-01-09 22:13:03
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JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
| Name | JNJ-5207852 dihydrochloride |
|---|
| Description | JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively. |
|---|---|
| Related Catalog | |
| Target |
H3 Receptor:8.9 (pKi, for rat) H3 Receptor:9.24 (pKi, for human) |
| In Vivo | JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1]. Animal Model: Male, Sprague-Dawley rats weighing 282-334 g[1]. Dosage: 3, 10, 30 mg/kg. Administration: S.C. Result: Iincreased time spent awake and decreased REM sleep and slow-wave sleep. |
| References |
| Molecular Formula | C20H34Cl2N2O |
|---|---|
| Molecular Weight | 389.40 |
| Hazard Codes | Xn |
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