847727-81-5
847727-81-5 structure
- Name: AAT-008
- Chemical Name: 4-[(1S)-1-({[5-Chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl}amino)ethyl]benzoic acid
- CAS Number: 847727-81-5
- Molecular Formula: C21H16ClFN2O4
- Molecular Weight: 414.814
- Create Date: 2020-01-11 12:38:53
- Modify Date: 2024-01-12 06:07:25
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A novel potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM; shows little or no activity for hEP1/2/3 (IC50>1890 nM); inhibits PGE2-induced cAMP in human EP4 transfectant with pA2 of 8.97; exhibits significantly improved pharmacological profiles over grapiprant in acute and chronic inflammatory pain models in rats.
| Name | 4-[(1S)-1-({[5-Chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl}amino)ethyl]benzoic acid |
|---|---|
| Synonyms |
Benzoic acid, 4-[(1S)-1-[[[5-chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl]amino]ethyl]-
4-[(1S)-1-({[5-Chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl}amino)ethyl]benzoic acid |
| Description | A novel potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM; shows little or no activity for hEP1/2/3 (IC50>1890 nM); inhibits PGE2-induced cAMP in human EP4 transfectant with pA2 of 8.97; exhibits significantly improved pharmacological profiles over grapiprant in acute and chronic inflammatory pain models in rats. |
|---|---|
| References | References 1. Okumura Y, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1186-1192. View Related Products by Target Prostaglandin Receptor |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 583.4±50.0 °C at 760 mmHg |
| Molecular Formula | C21H16ClFN2O4 |
| Molecular Weight | 414.814 |
| Flash Point | 306.6±30.1 °C |
| Exact Mass | 414.078278 |
| LogP | 4.87 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.619 |