1050656-06-8

1050656-06-8 structure

Name: MF-766
Chemical Name: MF-766
CAS Number: 1050656-06-8
Molecular Formula: C₂₇H₂₁F₃N₂O₃
Molecular Weight: 478.462
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2020-01-11 17:15:51
Modify Date: 2024-01-08 11:16:04
MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.

Name	MF-766
Synonyms	Benzoic acid, 4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indol-7-yl]carbonyl]amino]cyclopropyl]- MF-766 86KF5VSV88 4-{1-[({1-[4-(Trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid

Description	MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.
References	References 1. Colucci J, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3. View Related Products by Target Prostaglandin Receptor