MF-766
Modify Date: 2024-01-08 11:16:04
MF-766 structure
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Common Name | MF-766 | ||
|---|---|---|---|---|
| CAS Number | 1050656-06-8 | Molecular Weight | 478.462 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 711.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C27H21F3N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 384.1±32.9 °C | |
Use of MF-766MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling. |
| Name | MF-766 |
|---|---|
| Synonym | More Synonyms |
| Description | MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling. |
|---|---|
| References | References 1. Colucci J, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3760-3. View Related Products by Target Prostaglandin Receptor |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 711.4±60.0 °C at 760 mmHg |
| Molecular Formula | C27H21F3N2O3 |
| Molecular Weight | 478.462 |
| Flash Point | 384.1±32.9 °C |
| Exact Mass | 478.150421 |
| LogP | 5.12 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.628 |
| Benzoic acid, 4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indol-7-yl]carbonyl]amino]cyclopropyl]- |
| MF-766 |
| 86KF5VSV88 |
| 4-{1-[({1-[4-(Trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid |