1622291-66-0
1622291-66-0 structure
- Name: PF-06462894
- Chemical Name: PF-06462894
- CAS Number: 1622291-66-0
- Molecular Formula: C18H23N3O3
- Molecular Weight: 329.393
- Create Date: 2020-01-11 14:23:35
- Modify Date: 2024-01-17 17:13:36
-
A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM; possesses favorable properties and a predicted low clinical dose (2 mg twice daily), does not show any evidence of immune activation in a mouse drug allergy model.
| Name | PF-06462894 |
|---|---|
| Synonyms |
6(R)-(2,2-Dimethyl-propyl)-2-(pyridin-2-ylmethoxy)-6,7-dihydro-9H-pyrimido[2,1-c][1,4]oxazin-4-one
Pyrimido[2,1-c][1,4]oxazin-4(9H)-one, 6-(2,2-dimethylpropyl)-6,7-dihydro-2-(2-pyridinylmethoxy)-, (6R)- (6R)-6-(2,2-Dimethylpropyl)-2-(2-pyridinylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one MFCD28137683 PF-06462894 |
| Description | A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM; possesses favorable properties and a predicted low clinical dose (2 mg twice daily), does not show any evidence of immune activation in a mouse drug allergy model. |
|---|---|
| References | References 1. Stepan AF, et al. J Med Chem. 2017 Sep 28;60(18):7764-7780. View Related Products by Target mGluR |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 487.1±55.0 °C at 760 mmHg |
| Molecular Formula | C18H23N3O3 |
| Molecular Weight | 329.393 |
| Flash Point | 248.4±31.5 °C |
| Exact Mass | 329.173950 |
| LogP | 1.35 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.593 |