408303-44-6

408303-44-6 structure

Name: GW-766994 R-form
Chemical Name: 4-{[({[(2R)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide
CAS Number: 408303-44-6
Molecular Formula: C₂₁H₂₄Cl₂N₄O₃
Molecular Weight: 451.346
Create Date: 2020-01-11 09:20:57
Modify Date: 2024-06-04 09:20:42
GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.

Name	4-{[({[(2R)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide
Synonyms	4-{[({[(2R)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide Benzamide, 4-[[[[[[(2R)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-

Description	GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
References	References 1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16. View Related Products by Target Chemokine Receptor (CCR and CXCR)