1266240-89-4
1266240-89-4 structure
- Name: IKK2-IN-9
- Chemical Name: IKK2-IN-9
- CAS Number: 1266240-89-4
- Molecular Formula: C20H22N6OS
- Molecular Weight: 394.497
- Create Date: 2020-01-12 22:52:44
- Modify Date: 2024-04-09 13:31:01
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IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation.
| Name | IKK2-IN-9 |
|---|
| Description | IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation. |
|---|---|
| References | References 1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. View Related Products by Target IκB kinase (IKK) |
| Molecular Formula | C20H22N6OS |
|---|---|
| Molecular Weight | 394.497 |