IKK2-IN-9
Modify Date: 2024-04-09 13:31:01
IKK2-IN-9 structure
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Common Name | IKK2-IN-9 | ||
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| CAS Number | 1266240-89-4 | Molecular Weight | 394.497 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H22N6OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IKK2-IN-9IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation. |
| Name | IKK2-IN-9 |
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| Description | IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation. |
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| References | References 1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. View Related Products by Target IκB kinase (IKK) |
| Molecular Formula | C20H22N6OS |
|---|---|
| Molecular Weight | 394.497 |