1319738-41-4
1319738-41-4 structure
- Name: BI1002494 trifluoroacetate
- Chemical Name: BI1002494 trifluoroacetate
- CAS Number: 1319738-41-4
- Molecular Formula: C25H26F3N3O7
- Molecular Weight: 537.492
- Create Date: 2020-01-12 11:05:50
- Modify Date: 2024-01-07 19:22:21
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A novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin); inhibits high-affinity IgE receptor-mediated mast cell and basophil degranulation (IC50=115 nM), 7-fold lower potency for blocking CD69 expression after anti-IgD (BCR) stimulation of peripheral B cells; dose-dependently inhibited OVA-induced bronchioalveolar lavage eosinophils in brown Norway rats.
| Name | BI1002494 trifluoroacetate |
|---|
| Description | A novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin); inhibits high-affinity IgE receptor-mediated mast cell and basophil degranulation (IC50=115 nM), 7-fold lower potency for blocking CD69 expression after anti-IgD (BCR) stimulation of peripheral B cells; dose-dependently inhibited OVA-induced bronchioalveolar lavage eosinophils in brown Norway rats. |
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| References | References 1. Lamb DJ, et al. J Pharmacol Exp Ther. 2016 Jun;357(3):554-61. View Related Products by Target Syk |
| Molecular Formula | C25H26F3N3O7 |
|---|---|
| Molecular Weight | 537.492 |