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  • DC Chemicals Limited
  • China
  • Product Name: SKI-2852
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1346554-47-9

1346554-47-9 structure
1346554-47-9 structure
  • Name: SKI-2852
  • Chemical Name: SKI-2852
  • CAS Number: 1346554-47-9
  • Molecular Formula: C27H34FN5O4S
  • Molecular Weight: 543.658
  • Create Date: 2020-01-20 17:57:56
  • Modify Date: 2024-09-08 13:06:53
  • A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.

Name SKI-2852
Description A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.
References References 1. Ryu JH, et al. J Med Chem. 2016 Nov 23;59(22):10176-10189. View Related Products by Target 11β-HSD
Molecular Formula C27H34FN5O4S
Molecular Weight 543.658