1354742-60-1
1354742-60-1 structure
- Name: YLC2-155
- Chemical Name: YLC2-155
- CAS Number: 1354742-60-1
- Molecular Formula: C13H9NO4
- Molecular Weight: 243.22
- Create Date: 2020-01-12 09:40:49
- Modify Date: 2024-10-01 18:35:17
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YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays.
| Name | YLC2-155 |
|---|
| Description | YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays. |
|---|---|
| References | References 1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17. 2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61. View Related Products by Target HIV |
| Molecular Formula | C13H9NO4 |
|---|---|
| Molecular Weight | 243.22 |