1430611-24-7
1430611-24-7 structure
- Name: CCG-203586
- Chemical Name: CCG-203586
- CAS Number: 1430611-24-7
- Molecular Formula: C26H32N2O4
- Molecular Weight: 436.552
- Create Date: 2020-01-20 18:11:57
- Modify Date: 2025-08-25 11:01:17
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A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM; inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1; significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice.
| Name | CCG-203586 |
|---|
| Description | A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM; inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1; significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice. |
|---|---|
| References | References 1. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91. 2. Arthur JR, et al. Neurochem Res. 2013 Apr;38(4):866-75. View Related Products by Target Other Targets |
| Molecular Formula | C26H32N2O4 |
|---|---|
| Molecular Weight | 436.552 |