156177-59-2
156177-59-2 structure
- Name: CEP-751
- Chemical Name: CEP-751
- CAS Number: 156177-59-2
- Molecular Formula: C27H23N3O4
- Molecular Weight: 453.4957
- Create Date: 2020-01-11 15:07:49
- Modify Date: 2024-09-20 23:18:54
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A potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC; shows weak inhibition for PDGFR and bFGFR, has no effect on EGF, IGF-I, insulin, ErbB receptors; exhibits anti-tumor efficacy against tumors derived from NIH3T3 cells transfected with trkA; inhibits tumor growth in MTC cell xenografts.
| Name | CEP-751 |
|---|
| Description | A potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC; shows weak inhibition for PDGFR and bFGFR, has no effect on EGF, IGF-I, insulin, ErbB receptors; exhibits anti-tumor efficacy against tumors derived from NIH3T3 cells transfected with trkA; inhibits tumor growth in MTC cell xenografts. |
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| References | References 1. Camoratto AM, et al. Int J Cancer. 1997 Aug 7;72(4):673-9. 2. Dionne CA, et al. Clin Cancer Res. 1998 Aug;4(8):1887-98. 3. Strock CJ, et al. Cancer Res. 2003 Sep 1;63(17):5559-63. View Related Products by Target Trk Receptor |
| Molecular Formula | C27H23N3O4 |
|---|---|
| Molecular Weight | 453.4957 |