2158198-77-5
2158198-77-5 structure
- Name: Sulfotransferase-IN-1
- Chemical Name: Sulfotransferase-IN-1
- CAS Number: 2158198-77-5
- Molecular Formula: C17H11BrCl2N2O3
- Molecular Weight: 442.09
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-01-12 11:05:48
- Modify Date: 2024-03-01 09:04:14
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The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth.
| Name | Sulfotransferase-IN-1 |
|---|
| Description | The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth. |
|---|---|
| References | References 1. Cheung ST, et al. ACS Chem Biol. 2017 Dec 15;12(12):3126-3133. View Related Products by Target Other Targets |
| Molecular Formula | C17H11BrCl2N2O3 |
|---|---|
| Molecular Weight | 442.09 |
| Hazard Codes | Xi |
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