2237234-47-6

2237234-47-6 structure

Name: FAK inhibitor 5
Chemical Name: FAK inhibitor 5
CAS Number: 2237234-47-6
Molecular Formula: C₂₈H₂₇ClN₈O₄
Molecular Weight: 575.026
Create Date: 2020-01-16 12:57:02
Modify Date: 2024-09-23 16:54:50
FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM; displays little to no inhibition against a panel of ten kinases (EGFR, HER2/ERBB2, IGF1R, c-Kit, PDGFR, Pyk2, c-Src, IRR, and IR); dose-dependently inhibits the proliferation with ED50 of 1.73 uM in SCC cells, blocks Tyr397 phosphorylation in a dose-dependent manner and significantly inhibits FAK autophosphorylation at low concentrations.

Name	FAK inhibitor 5

Description	FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM; displays little to no inhibition against a panel of ten kinases (EGFR, HER2/ERBB2, IGF1R, c-Kit, PDGFR, Pyk2, c-Src, IRR, and IR); dose-dependently inhibits the proliferation with ED50 of 1.73 uM in SCC cells, blocks Tyr397 phosphorylation in a dose-dependent manner and significantly inhibits FAK autophosphorylation at low concentrations.
References	References 1. Yen-Pon E, et al. ACS Chem Biol. 2018 Jun 13. doi: 10.1021/acschembio.8b00250. View Related Products by Target Focal Adhesion Kinase (FAK)

Molecular Formula	C₂₈H₂₇ClN₈O₄
Molecular Weight	575.026