FAK inhibitor 5

Modify Date: 2024-09-23 16:54:50

FAK inhibitor 5 Structure
FAK inhibitor 5 structure
Common Name FAK inhibitor 5
CAS Number 2237234-47-6 Molecular Weight 575.026
Density N/A Boiling Point N/A
Molecular Formula C28H27ClN8O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FAK inhibitor 5


FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM; displays little to no inhibition against a panel of ten kinases (EGFR, HER2/ERBB2, IGF1R, c-Kit, PDGFR, Pyk2, c-Src, IRR, and IR); dose-dependently inhibits the proliferation with ED50 of 1.73 uM in SCC cells, blocks Tyr397 phosphorylation in a dose-dependent manner and significantly inhibits FAK autophosphorylation at low concentrations.

 Names

Name FAK inhibitor 5

 FAK inhibitor 5 Biological Activity

Description FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM; displays little to no inhibition against a panel of ten kinases (EGFR, HER2/ERBB2, IGF1R, c-Kit, PDGFR, Pyk2, c-Src, IRR, and IR); dose-dependently inhibits the proliferation with ED50 of 1.73 uM in SCC cells, blocks Tyr397 phosphorylation in a dose-dependent manner and significantly inhibits FAK autophosphorylation at low concentrations.
References References 1. Yen-Pon E, et al. ACS Chem Biol. 2018 Jun 13. doi: 10.1021/acschembio.8b00250. View Related Products by Target Focal Adhesion Kinase (FAK)

 Chemical & Physical Properties

Molecular Formula C28H27ClN8O4
Molecular Weight 575.026
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