1192348-73-4
1192348-73-4 structure
- Name: TAK-259
- Chemical Name: TAK-259
- CAS Number: 1192348-73-4
- Molecular Formula: C14H13Cl2N3O3S
- Molecular Weight: 374.236
- Create Date: 2020-01-20 14:53:56
- Modify Date: 2024-04-05 18:39:57
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A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats. Other Indication Phase 1 Discontinued
| Name | TAK-259 |
|---|
| Description | A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats. Other Indication Phase 1 Discontinued |
|---|---|
| References | References 1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002. View Related Products by Target Adrenergic Receptor Other Indication |
| Molecular Formula | C14H13Cl2N3O3S |
|---|---|
| Molecular Weight | 374.236 |