1197420-12-4
1197420-12-4 structure
- Name: BMS 814580 phosphate
- Chemical Name: BMS 814580 phosphate
- CAS Number: 1197420-12-4
- Molecular Formula: C24H20ClF2N2O7PS
- Molecular Weight: 584.912
- Create Date: 2020-01-12 07:15:50
- Modify Date: 2024-01-15 20:00:19
-
A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in chronic diet-induced obese models with excellent safety profile.
| Name | BMS 814580 phosphate |
|---|
| Description | A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in chronic diet-induced obese models with excellent safety profile. |
|---|---|
| References | References 1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR) |
| Molecular Formula | C24H20ClF2N2O7PS |
|---|---|
| Molecular Weight | 584.912 |