1202761-92-9
1202761-92-9 structure
- Name: AM-0216
- Chemical Name: Amgen16
- CAS Number: 1202761-92-9
- Molecular Formula: C19H19ClN4O
- Molecular Weight: 354.838
- Create Date: 2020-01-12 11:50:49
- Modify Date: 2024-09-17 17:07:10
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Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.
| Name | Amgen16 |
|---|
| Description | Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors. |
|---|---|
| References | References 1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66. 2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216. View Related Products by Target NF-κB inducing Kinase (NIK) |
| Molecular Formula | C19H19ClN4O |
|---|---|
| Molecular Weight | 354.838 |