AM-0216
Modify Date: 2025-09-10 19:46:14
AM-0216 structure
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Common Name | AM-0216 | ||
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| CAS Number | 1202761-92-9 | Molecular Weight | 354.838 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19ClN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AM-0216Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors. |
| Name | Amgen16 |
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| Description | Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors. |
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| References | References 1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66. 2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216. View Related Products by Target NF-κB inducing Kinase (NIK) |
| Molecular Formula | C19H19ClN4O |
|---|---|
| Molecular Weight | 354.838 |
| InChIKey | KJIQYGRWNLGGMI-UHFFFAOYSA-N |
| SMILES | Nc1ncc(Cl)c(N2CCc3ccc(C#CC4(O)CCCC4)cc32)n1 |