1235406-09-3
1235406-09-3 structure
- Name: GX-936
- Chemical Name: GX-936
- CAS Number: 1235406-09-3
- Molecular Formula: C24H20F3N7O3S2
- Molecular Weight: 575.585
- Create Date: 2020-01-11 16:40:50
- Modify Date: 2024-11-29 20:07:33
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GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM; inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.
| Name | GX-936 |
|---|
| Description | GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM; inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. |
|---|---|
| References | References 1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464. 2. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. View Related Products by Target Sodium Channel |
| Molecular Formula | C24H20F3N7O3S2 |
|---|---|
| Molecular Weight | 575.585 |