GX-936
Modify Date: 2025-09-14 14:25:40
GX-936 structure
|
Common Name | GX-936 | ||
|---|---|---|---|---|
| CAS Number | 1235406-09-3 | Molecular Weight | 575.585 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H20F3N7O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GX-936GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM; inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. |
| Name | GX-936 |
|---|
| Description | GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM; inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. |
|---|---|
| References | References 1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464. 2. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. View Related Products by Target Sodium Channel |
| Molecular Formula | C24H20F3N7O3S2 |
|---|---|
| Molecular Weight | 575.585 |
| InChIKey | UCAVSLIXTXZSRD-UHFFFAOYSA-N |
| SMILES | CCN1CC(n2nccc2-c2cc(C(F)(F)F)ccc2Oc2ccc(S(=O)(=O)Nc3ncns3)cc2C#N)C1 |