1242279-00-0
1242279-00-0 structure
- Name: WF-210
- Chemical Name: WF-210
- CAS Number: 1242279-00-0
- Molecular Formula: C41H38FN7O7S
- Molecular Weight: 791.855
- Create Date: 2020-01-11 20:03:49
- Modify Date: 2024-09-17 22:05:49
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WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models.
| Name | WF-210 |
|---|
| Description | WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models. |
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| References | References 1. Wang F, et al. Eur J Pharmacol. 2018 Feb 15;821:29-38. 2. Wang F, et al. Mol Oncol. 2014 Dec;8(8):1640-52. View Related Products by Target Caspase |
| Molecular Formula | C41H38FN7O7S |
|---|---|
| Molecular Weight | 791.855 |