537034-17-6

537034-17-6 structure

Name: BML-210
Chemical Name: bml-210
CAS Number: 537034-17-6
Molecular Formula: C₂₀H₂₅N₃O₂
Molecular Weight: 339.431
Catalog: Research Areas Cancer
Create Date: 2016-04-21 10:22:28
Modify Date: 2025-08-25 18:19:54
BML-210 is a novel HDAC inhibitor, and its mechanism of action has not been characterized.IC50 value: 5 μM[1]Target: HDAC4In vitro: Cell cycle analysis indicated that HeLa cell treatment with 20 and 30 μM concentration of BML-210 increased the proportion of cells in G0/G1 phase, and caused accumulation in subG1, indicating that the cells are undergoing apoptosis[2]. BML-210 inhibits the growth of NB4 cells in dose- and time-dependent manner[3].In vivo:

Name	bml-210
Synonyms	BML-210 N'-(2-aminophenyl)-N-phenyloctanediamide N-(2-Aminophenyl)-N'-phenyloctanediamide Octanediamide, N-(2-aminophenyl)-N-phenyl-

Description	BML-210 is a novel HDAC inhibitor, and its mechanism of action has not been characterized.IC50 value: 5 μM[1]Target: HDAC4In vitro: Cell cycle analysis indicated that HeLa cell treatment with 20 and 30 μM concentration of BML-210 increased the proportion of cells in G0/G1 phase, and caused accumulation in subG1, indicating that the cells are undergoing apoptosis[2]. BML-210 inhibits the growth of NB4 cells in dose- and time-dependent manner[3].In vivo:
Related Catalog	Research Areas >> Cancer
Target	HDAC4:MEF2
References	[1]. Nimanthi Jayathilaka, et al. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res. 2012 Jul; 40(12): 5378–5388. [2]. Veronika V. Borutinskaite, et al. Histone deacetylase inhibitor BML-210 induces growth inhibitionand apoptosis and regulates HDAC and DAPC complexexpression levels in cervical cancer cells. Mol Biol Rep (2012) 39:10179–10186 [3]. Veronika Borutinskaite, et al. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015 Aug; 16(8): 18252–18269.

Hazard Statements	H413
RIDADR	NONH for all modes of transport